I have a PKPD system I worked through the differential equations suite from Chris and would like to compare my results with Pumas. My system consists of 11 actuall differential equations and 5 algebraic equations that inform the differential equations.

For example

dCc/dt = (-K1-KE)*Cc + K2*Cp (Concentration = transfer from periferal - elimination from Central - transfer to periferal)

dV1/dt = TG-TD (subVolume = growth - death)

death= Kd*Cc
growth = Kg*V

V=V1+V2+V3+v4

This is clearly not the system (willing to share if you want), but as you see my algebaric equations do not belong in post processing as their values are linked to dynamic parameters that change during the solution of the system.

After reading the tutorials I am not sure in which section of the model should I define them.

Could you please help me with that?

Thanks,

A