How to calculate average steady-state plasma concentration

1

I wanted to calculated average steady-state plasma concentration. is there any method of doing it in Pumas??

2

Hi Sucharita,

What is your input? Do you have single dose data? Do you prefer NCA based or model based approach?

Best,
Vijay

3

I need input for both single dose and multiple dose data. And a model based approach

Regards,
Sucharitha

4

The easiest way is to use the formulas AUC = Dose/CL and Cavg = AUC/tau. If you have already fitted a model, you can get the individual posthoc estimates of CL from the icoef(fitted_model) function in Pumas. I hope this helps!

5

Thank you for the reply.