How to calculate average steady-state plasma concentration

I wanted to calculated average steady-state plasma concentration. is there any method of doing it in Pumas??

Hi Sucharita,

What is your input? Do you have single dose data? Do you prefer NCA based or model based approach?


I need input for both single dose and multiple dose data. And a model based approach


The easiest way is to use the formulas AUC = Dose/CL and Cavg = AUC/tau. If you have already fitted a model, you can get the individual posthoc estimates of CL from the icoef(fitted_model) function in Pumas. I hope this helps!

Thank you for the reply.