After I created a 1-compartment oral pk model in Pumas, it should that Dynamical system type: Closed form under PumasModel. What does it do or mean for Pumus Model?
Hello Limei,
It means that Pumas will solve the dynamical system using a closed-form solution instead of numerically integrating the ODE. Using a closed-form solution is both much faster and much more accurate, but it is only available for some dynamical systems. E.g., it is not possible for Pumas to solve with a closed-form solution if the individual parameters depend on time, except in the case where this dependence is via time-varying covariates since we then treat them as piece-wise constant.
Thanks a lot for the explanation. That’s make sense to my model since it dosen’t have time or dose event.
Dose events can also be handled by closed-form solutions. What isn’t covered by the closed form solutions if you e.g. time dependent clearance.