How to use regressors?

Basic Usage model-syntax
1

How do I make use of regressors? To be more specific:
I have a dataset with PD measurements after a number of different doses described by the :dosegrp column. Now, I’m trying to set up a simple turnover model such as

ddt_E = kin*(1-Imax*Cc/(Cc+IC50)) - kout*E

where Cc is informed by the :dosegrp column.

In Monolix, for instance, I can define the column as regressor and then use Cc = {use=regressor} in the model file.

2

If Cc is part of your dataset, the bring in Cc as a covariate by specifying it in read_pumas and then in your @covariates block

1 Like
3

Thanks @vijay. Works great!