Hi, I have a PKPD data where the PD information is not available for all subjects. The fit function works when I include only subjects with both PK and PD information available, however , when I try to fit the whole data I get an error saying that there are subjects with missing PD information.
I was assuming that when subject has missing PD information the random effects for PK parameters should be zero and the typical PK profile should be used for estimation of PD parameters.
Does Pumas allows simultaneous PKPD modeling only when all subjects have complete PKPD information?