Hello. With the recent 2.7 update I have some simulation code that now errors (the last few weeks it’s been running and generating accurate results, but with the recent update it no longer runs). I apologize that I cannot post the code here. Every time I click the preformatted text option discourse crashes. Even when trying to paste the model code/error in the general text box, discourse tries to assume I want to use preformatted text and crashes again (it is not a long error message or code). This isn’t just your discourse - this is also happening on our University discourse channel. You can imagine my frustration I’d be happy to email details, but I have described the scenario below none the less:
The code I’m running simulates a single steady-state 24-hour dosing interval and utilizes the observed block to output NCA parameters (cmaxss, cminss, and auc0-24hr,ss). I was able to diagnose the source of the problem, which is that whenever I utilize SS=1 I get an error using simobs(). If I change the code to not assume steady state, it runs without problem (outputs cmax, auc0-24hr). I can get simulated steady state NCA parameters by converting resulting steady-state concentration-time data to a dataframe, mapping the data, and manually performing NCA outside of the observed block… but it was a lot more convenient before. Is this a known bug or is there something that has changed with performing NCA for SS=1 or within the observed block for a simulation?