Issue in simulation using EVID = 4

Simulation
1

Hello,

I am trying to simulate PK for a crossover study design where each subject gets 4 different formulations (for periods 1, 2, 3, and 4). I want to simulate such that the compartments reset at the time of dosing during periods 2, 3, and 4. I tried doing this by setting evid = 1 for period 1 and evid = 4 for periods 2, 3, and 4 in the population but the simulations were not correct. I wonder if my population is set up correctly.

Regards,
Pawan

2

hi Pawan,

Thank you for the report. Could you be a little bit more specific about the exact issue that led you to the conclusion that the simulations are not correct?

Best,
Vijay