IOV modeling and simulation

[donaldlee3]

Hi @clee,

Please also see this post for more information about IOV in Pumas:

SAME option for BOV

Hello, Is there something similar to the SAME option in NONMEM to estimate one BOV, instead of a BOV per occasion? If so, could I get an example of how it’s done in Pumas? Thank you.

For your data set, you will want to have a single OCC column with 1-4/5 for each cycle of dialysis.

Regarding your 2), if I understand you correctly, you may want to do something like the choose_covariates function here: https://tutorials.pumas.ai/html/simulation/simulating_populations.html . So, you’ll determine each subject’s OCC column based on whatever criteria you choose for that given subject, and then pass OCC as a covariate.