# RSE in NONMEM vs Pumas

**URL:** <https://discourse.pumas.ai/t/rse-in-nonmem-vs-pumas/764>\
**Category:** Estimation\
**Created:** [September 20, 2022, 4:47pm UTC](https://discourse.pumas.ai/t/rse-in-nonmem-vs-pumas/764 "2022-09-20T16:47:03Z")\
**Posts on this page:** 3\
**Page:** 1

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**Author:** ![adunn34](https://yyz2.discourse-cdn.com/flex030/user_avatar/discourse.pumas.ai/adunn34/32/204_2.png) [@adunn34](https://discourse.pumas.ai/u/adunn34)\
**Post date:** [September 20, 2022, 4:47pm UTC](https://discourse.pumas.ai/t/rse-in-nonmem-vs-pumas/764/1 "2022-09-20T16:47:03Z")

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Hello - for SE estimations is there a particular method I should be using in Pumas to match with NONMEM? I’m reproducing some work done in NONMEM and wanted to figure out how to get my RSE calculation to align.

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**Author:** ![vijay](https://yyz2.discourse-cdn.com/flex030/user_avatar/discourse.pumas.ai/vijay/32/96_2.png) [@vijay](https://discourse.pumas.ai/u/vijay)\
**Post date:** [September 20, 2022, 5:38pm UTC](https://discourse.pumas.ai/t/rse-in-nonmem-vs-pumas/764/2 "2022-09-20T17:38:10Z")

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1. do the estimates match?
2. when using `infer` are you using the default settings? If so, they should be the same as NONMEM.
3. What is the nonmem $COVARIANCE look like?

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**Author:** ![adunn34](https://yyz2.discourse-cdn.com/flex030/user_avatar/discourse.pumas.ai/adunn34/32/204_2.png) [@adunn34](https://discourse.pumas.ai/u/adunn34)\
**Post date:** [September 20, 2022, 8:54pm UTC](https://discourse.pumas.ai/t/rse-in-nonmem-vs-pumas/764/3 "2022-09-20T20:54:03Z")

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Ok good to know - I figured out the discrepancy & RSE is matching now. Thanks for the guidance.